Compounds > N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide
Page last updated: 2024-09-05

N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide and ponatinib

N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide has been researched along with ponatinib in 1 studies

Compound Research Comparison

Studies
(N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide)		Trials
(N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide)		Recent Studies (post-2010)
(N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide)		Studies
(ponatinib)		Trials
(ponatinib)		Recent Studies (post-2010) (ponatinib)
90753834519

Protein Interaction Comparison

ProteinTaxonomyN-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide (IC50)ponatinib (IC50)
Receptor-interacting serine/threonine-protein kinase 2Homo sapiens (human)0.0038
Tyrosine-protein kinase JAK2Homo sapiens (human)0.169
Tyrosine-protein kinase ABL1Homo sapiens (human)0.0037
Proto-oncogene tyrosine-protein kinase SrcGallus gallus (chicken)0.0009
High affinity nerve growth factor receptorHomo sapiens (human)0.0114
Tyrosine-protein kinase LckHomo sapiens (human)0.0003
Tyrosine-protein kinase FynHomo sapiens (human)0.0004
Macrophage colony-stimulating factor 1 receptorHomo sapiens (human)0.0086
Tyrosine-protein kinase YesHomo sapiens (human)0.0009
Tyrosine-protein kinase LynHomo sapiens (human)0.0008
Proto-oncogene tyrosine-protein kinase receptor RetHomo sapiens (human)0.0357
Hepatocyte growth factor receptorHomo sapiens (human)0.0017
Tyrosine-protein kinase HCKHomo sapiens (human)0.0001
Platelet-derived growth factor receptor betaHomo sapiens (human)0.0012
Mast/stem cell growth factor receptor KitHomo sapiens (human)0.0271
Breakpoint cluster region proteinHomo sapiens (human)0.0008
Fibroblast growth factor receptor 1Homo sapiens (human)0.0016
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)0.0053
Platelet-derived growth factor receptor alphaHomo sapiens (human)0.0016
cAMP-dependent protein kinase catalytic subunit alphaHomo sapiens (human)0.613
Vascular endothelial growth factor receptor 1 Homo sapiens (human)0.0123
Ephrin type-A receptor 1Homo sapiens (human)0.143
Fibroblast growth factor receptor 2Homo sapiens (human)0.0018
Fibroblast growth factor receptor 4Homo sapiens (human)0.0058
Fibroblast growth factor receptor 3Homo sapiens (human)0.0099
Tyrosine-protein kinase JAK1Homo sapiens (human)0.0322
Ephrin type-A receptor 2Homo sapiens (human)0.0013
Vascular endothelial growth factor receptor 2Homo sapiens (human)0.0053
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)0.0086
Tyrosine-protein kinase CSKHomo sapiens (human)0.0127
Tyrosine-protein kinase FRKHomo sapiens (human)0.0013
Glycogen synthase kinase-3 betaHomo sapiens (human)2.8
Epithelial discoidin domain-containing receptor 1Homo sapiens (human)0.0094
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)4.385
Receptor-interacting serine/threonine-protein kinase 1Homo sapiens (human)0.012
Coiled-coil domain-containing protein 6Homo sapiens (human)0.1804
Mitogen-activated protein kinase 14Homo sapiens (human)0.01
Leucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)0.48
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)0.04
Receptor-interacting serine/threonine-protein kinase 3Homo sapiens (human)0.0016

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1

Other Studies

1 other study(ies) available for N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide and ponatinib

ArticleYear
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013